Bone marrow drug could treat alopecia “Alopecia sufferers given new treatment hope with repurposed drug,” The Guardian reports.
Alopecia is a type of autoimmune condition where the body’s own immune cells start to attack the hair follicles for an unknown reason, leading to hair loss.
This new research actually involved two phases, one involving mice and one involving humans.
The researchers identified the specific type of immune cell (CD8+NKG2D+ T cells) that is involved in this autoimmune process, and identified the signalling pathways that stimulate the activity of these cells.
The researchers then demonstrated that using molecular treatments to block these signalling pathways was effective in preventing and reversing the disease process in mice genetically engineered to develop alopecia.
These findings in mice were followed by promising results in three people with moderate to severe alopecia. These people were treated with ruxolitinib, which is currently licensed in the UK to treat certain bone marrow disorders. All three patients demonstrated “near-complete hair regrowth” after three to five months of treatment.
Alopecia is a type of autoimmune condition where the body’s own immune cells start to attack the hair follicles for an unknown reason, leading to hair loss.
This new research actually involved two phases, one involving mice and one involving humans.
The researchers identified the specific type of immune cell (CD8+NKG2D+ T cells) that is involved in this autoimmune process, and identified the signalling pathways that stimulate the activity of these cells.
The researchers then demonstrated that using molecular treatments to block these signalling pathways was effective in preventing and reversing the disease process in mice genetically engineered to develop alopecia.
These findings in mice were followed by promising results in three people with moderate to severe alopecia. These people were treated with ruxolitinib, which is currently licensed in the UK to treat certain bone marrow disorders. All three patients demonstrated “near-complete hair regrowth” after three to five months of treatment.